# --------------------------------------------
# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "crm12Comb" in publications use:'
type: software
license: GPL-3.0-or-later
title: 'crm12Comb: Phase I/II CRM Based Drug Combination Design'
version: 0.1.12
doi: 10.1371/journal.pone.0336146
identifiers:
- type: doi
  value: 10.32614/CRAN.package.crm12Comb
abstract: 'Implements the adaptive designs for integrated phase I/II trials of drug
  combinations via continual reassessment method (CRM) to evaluate toxicity and efficacy
  simultaneously for each enrolled patient cohort based on Bayesian inference. It
  supports patients assignment guidance in a single trial using current enrolled data,
  as well as conducting extensive simulation studies to evaluate operating characteristics
  before the trial starts. It includes various link functions such as empiric, one-parameter
  logistic, two-parameter logistic, and hyperbolic tangent, as well as considering
  multiple prior distributions of the parameters like normal distribution, gamma distribution
  and exponential distribution to accommodate diverse clinical scenarios. Method using
  Bayesian framework with empiric link function is described in: Wages and Conaway
  (2014) <https://doi.org/10.1002/sim.6097>.'
authors:
- family-names: Wang
  given-names: Junying
  email: junying.wang.dl@gmail.com
- family-names: Wu
  given-names: Song
  email: song.wu@stonyrbook.edu
- family-names: Yang
  given-names: Jie
  email: jie.yang@stonyrbookmedicine.edu
preferred-citation:
  type: article
  title: 'crm12comb: Phase I/II adaptive design for drug combinations based on CRM
    design through R'
  authors:
  - family-names: Wang
    given-names: Junying
    email: junying.wang.dl@gmail.com
  - family-names: Wu
    given-names: Song
    email: song.wu@stonyrbook.edu
  - family-names: Yang
    given-names: Jie
    email: jie.yang@stonyrbookmedicine.edu
  journal: PLoS One
  year: '2025'
  volume: '20'
  issue: '11'
  doi: 10.1371/journal.pone.0336146
  start: e0336146
repository: https://junying23.r-universe.dev
commit: dccb975f7defc4ec7e9e1ab9a602ed0aed597990
date-released: '2026-02-03'
contact:
- family-names: Wang
  given-names: Junying
  email: junying.wang.dl@gmail.com