To cite this package in publications, please use: Wang J, Wu S, Yang J (2025). “crm12comb: Phase I/II adaptive design for drug combinations based on CRM design through R.” _PLoS One_, *20*(11), e0336146. doi:10.1371/journal.pone.0336146 . A BibTeX entry for LaTeX users is @Article{, title = {crm12comb: Phase I/II adaptive design for drug combinations based on CRM design through R}, author = {Junying Wang and Song Wu and Jie Yang}, journal = {PLoS One}, year = {2025}, volume = {20}, number = {11}, pages = {e0336146}, doi = {10.1371/journal.pone.0336146}, }